Sedating antihistamines mechanism of action fun online dating


27-Jan-2018 11:30

Diphenhydramine and promethazine are actually more potent than procaine as local anesthetics.They are occasionally used to produce local anesthesia in patients allergic to conventional local anesthetic drugs.Sedatives are a diverse group of drugs manufactured for medical purposes to relax the central nervous system.Also known as tranquillizers or central nervous system (CNS) depressants, they encompass drug classes such as barbiturates, benzodiazepines, non-benzodiazepine sedative-hypnotics, anesthetics, antihistamines and opioid narcotics, as well as herbal compounds.The MED for chlorpheniramine and bromopheniramine was 3 and 10 mg/kg p.o., respectively.The PPD antihistamines, namely terfenadine and astemizole, inhibited cough (MED 30 and 10 mg/kg p.o.) without sedative effects.Because of their toxicity, bromides were replaced by barbiturates in the early 20th century, which were initially also heralded as effective and safe sedative drugs.However, in a short period of time problems with dependence, tolerance and lethal overdosing became evident.

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Secondary amine TCAs (e.g., nortriptyline) are generally believed to be less likely to cause orthostatic hypotension than tertiary amine TCAs.

Common side effects include sedation, carbohydrate craving, and weight gain.